Bell G A, Gibbs M E
Neurosci Lett. 1979 Jul;13(2):163-8. doi: 10.1016/0304-3940(79)90035-1.
Monocular training on a one-trial passive avoidance task in the young chick has been shown to establish an engram in the forebrain hemisphere contralateral to the trained eye, and hence interocular transfer of this task must involve the naive hemisphere making access to the engram in the opposite hemisphere. We have studied the consequences for the untrained hemisphere of accessing a unilateral engram during two short term stages of its consolidation, by conducting interocular transfer tests at 7.5 min and 30 min after learning, prior to onset of amnesia induced by intracranial injection of ouabain or cycloheximide. Testing the naive hemisphere 24 h later indicated that engram transfer had occurred in chicks receiving one access trial at 7.5 min, during the first stage of consolidation of the unilateral engram. At 30 min, during second consolidation stage, five access trials were required to achieve engram transfer. These experiments confirm the findings from the rat that engram transfer can follow from making access to the unilateral engram. However, it has not previously been recognised that interhemispheric memory transfer depends on the recency of formation of the unilateral engram.
研究表明，对幼雏进行单眼一次被动回避任务训练可在前脑半球中与训练眼对侧的半球建立记忆痕迹，因此该任务的眼间转移必然涉及未训练的半球获取对侧半球中的记忆痕迹。我们通过在学习后7.5分钟和30分钟进行眼间转移测试，研究了在记忆痕迹巩固的两个短期阶段中，未训练半球获取单侧记忆痕迹的后果，此时颅内注射哇巴因或环己酰亚胺诱导的遗忘尚未开始。24小时后对未训练半球进行测试表明，在单侧记忆痕迹巩固的第一阶段，在7.5分钟接受一次获取测试的雏鸡中发生了记忆痕迹转移。在30分钟，即第二巩固阶段，需要进行五次获取测试才能实现记忆痕迹转移。这些实验证实了大鼠实验的结果，即记忆痕迹转移可源于获取单侧记忆痕迹。然而，此前尚未认识到半球间记忆转移取决于单侧记忆痕迹形成的近期性。
