Reinhards J, Weber A, Nizetic B, Kupka K, Maxwell-Lyons F
Bull World Health Organ. 1968;39(4):497-545.
It has been noted in many parts of the world that bacterial conjunctivitis is a major cause of total or partial loss of vision. In addition, trachoma is aggravated if there are associated bacterial infections and these lead to more frequent corneal complications.In the trials described the seasonal variation of bacterial infections was studied in addition to trachoma in 3 pilot sectors in southern Morocco. The frequency of complications and late sequelae from these infections in the whole population of these sectors was also studied.In one of the sectors 3 different methods of limiting the regular seasonal increase in bacterial infections and of curing trachoma were evaluated separately or in combination. These included the effect of fly-suppression on the transmission of infection, a possible method of chemoprophylaxis, and intermittent treatment with chlortetracycline ointment.The effect of the latter, when applied to a whole population group by auxiliary personnel, was compared with the long-term effect of self-treatment, in this and the two other sectors.The total observation period covered 12 years.
在世界许多地区都已注意到,细菌性结膜炎是导致视力全部或部分丧失的主要原因。此外,如果伴有细菌感染,沙眼会加重,进而导致更频繁的角膜并发症。在所述试验中,除了在摩洛哥南部3个试点地区研究沙眼外,还研究了细菌感染的季节性变化。同时也研究了这些地区全体居民中这些感染引发并发症和晚期后遗症的频率。在其中一个地区,分别或联合评估了3种不同方法来限制细菌感染的季节性定期增加以及治疗沙眼。这些方法包括灭蝇对感染传播的影响、一种可能的化学预防方法,以及金霉素眼膏间歇治疗。将辅助人员对整个人群组应用金霉素眼膏的效果,与该地区以及其他两个地区自我治疗的长期效果进行了比较。总观察期长达12年。