震颤：纹状体胆碱能神经元的作用及纹状体内注射 kainic 酸的影响。

Tremor: role of striatal cholinergic neurons and the effect of intrastriatal kainic acid.

作者信息

Silbergeld E K, Hruska R E

出版信息

Neurosci Lett. 1979 Dec;15(2-3):235-42. doi: 10.1016/0304-3940(79)96119-6.

Abstract

Rats injected intrastriatally with kainic acid (KA) showed increased tremor responses to arecoline and tremorine, but not to harmaline. Since KA significantly reduced both pre- and postsynaptic measurements of cholinergic function in the striatum, the results indicate that integrity of the striatal cholinergic system is not essential to tremor response. Further investigations of cholinergic function in the brains of rats injected with KA did not reveal evidence of cholinergic supersensitivity; thus, the altered responses to cholinergic agents may reflect KA-associated destruction of some pathway normally opposing the behavioral output of cholinergic stimulation. If, as recently proposed, intrastriatal injection of KA produces an animal model of Huntington's disease (HD), then these results may also be relevant to experimental therapeutics of this disorder.

摘要

向大鼠纹状体内注射 kainic acid（KA）后，其对槟榔碱和震颤素的震颤反应增强，但对 harmaline 无此反应。由于 KA 显著降低了纹状体内胆碱能功能的突触前和突触后测量值，结果表明纹状体胆碱能系统的完整性对于震颤反应并非必不可少。对注射 KA 的大鼠大脑中胆碱能功能的进一步研究未发现胆碱能超敏反应的证据；因此，对胆碱能药物反应的改变可能反映了 KA 相关的某些通路破坏，这些通路通常与胆碱能刺激的行为输出相反。如果如最近所提出的，纹状体内注射 KA 可产生亨廷顿舞蹈症（HD）的动物模型，那么这些结果可能也与该疾病的实验治疗相关。