Simon H, Scatton B, Le Moal M
Neurosci Lett. 1979 Dec;15(2-3):319-24. doi: 10.1016/0304-3940(79)96133-0.
Prefrontal system dysfunction are revealed in rats in delayed response tasks. In view of the anatomical projections existing from the ventral mesencephalic tegmentum to the prefrontal system we have done this research in order to determine whether cognitive processes are impaired after mesencephalic lesions. Rats learned spatial delayed alternation in a T-maze. After acquisition they were randomly divided in two groups; the experimental group received lesions in the ventral mesencephalic tegmentum at the level of the A10 cell bodies. These lesions induced definitive disruption of the retention of the delayed alternation and the rats were unable to relearn the task. However, these animals were able to perform normally in an operant conditioning with food reinforcement indicating the specificity of the deficit observed with respect to the delayed alteration task. The possible modulating role of dopaminergic A10 neurones is hypothetized.
前额叶系统功能障碍在大鼠的延迟反应任务中表现出来。鉴于从中脑腹侧被盖区到前额叶系统存在解剖学投射，我们开展了这项研究，以确定中脑损伤后认知过程是否受损。大鼠在T型迷宫中学习空间延迟交替任务。习得后，它们被随机分为两组；实验组在A10细胞体水平的中脑腹侧被盖区接受损伤。这些损伤导致延迟交替任务的记忆巩固出现永久性破坏，大鼠无法重新学习该任务。然而，这些动物在食物强化的操作性条件反射中能够正常表现，这表明所观察到的缺陷相对于延迟交替任务具有特异性。推测了多巴胺能A10神经元可能的调节作用。
