突触前结构在耳蜗突触发生早期阶段的意义。

Significance of presynaptic formations in early stages of cochlear synaptogenesis.

作者信息

Pujol R, Carlier E, Devigne C

出版信息

Neurosci Lett. 1979 Dec;15(2-3):97-102. doi: 10.1016/0304-3940(79)96096-8.

Abstract

Very early stages of cochlear synaptogenesis are described in inner (IHCs) and outer hair cells (OHCs) of cat foetuses. Ten days before birth (DBB) well-formed synaptic contacts were found between afferent dendrites and both IHCs and OHCs. At the IHC level a preliminary stage before functioning has been proposed. But at the OHC level where the adult cell membrane becomes mainly postsynaptic, we could only formulate hypotheses based on phylogenetic considerations (afferents precede efferents), or on embryology (presynaptic specializations play a role in the arrival and growth of fibers around the hair cell).

摘要

猫胎儿的内毛细胞（IHCs）和外毛细胞（OHCs）中描述了耳蜗突触发生的非常早期阶段。出生前10天（DBB），在传入树突与IHCs和OHCs之间发现了形成良好的突触联系。在IHC水平上，已经提出了功能前的一个初步阶段。但在OHC水平上，成年细胞膜主要成为突触后膜，我们只能基于系统发育考虑（传入神经先于传出神经）或胚胎学（突触前特化在毛细胞周围纤维的到达和生长中起作用）来提出假设。