Newell F W, Stark P, Jay W M, Schanzlin D J
Ophthalmology. 1979 Jan;86(1):156-60. doi: 10.1016/s0161-6420(79)35539-7.
Nabilone is a synthesized crystalline benzopyran that resembles the cannabinols but is not a tetrahydrocannabinol. Oral administration of 0.5 to 2 mg to patients with open-angle glaucoma reduced the intraocular pressure from 10% to 54% with an average of 28%. Administration of a topical ophthalmic nabilone solution (0.1 mg/drop) to both eyes of adult albino rabbits (1.5 to 3.5 kg) lowered the IOP an average of 25%. The peak action of the nabilone administered in this manner was 60 minutes, with a return to normal IOP by 180 minutes. Tolerance developed in rabbits after one week of topical administration.
纳必隆是一种合成的结晶性苯并吡喃，它类似于大麻酚，但不是四氢大麻酚。给开角型青光眼患者口服0.5至2毫克纳必隆，可使眼压降低10%至54%，平均降低28%。给成年白化兔（体重1.5至3.5千克）双眼局部应用纳必隆眼药水（0.1毫克/滴），平均可使眼压降低25%。以这种方式给药的纳必隆的峰值作用时间为60分钟，180分钟后眼压恢复正常。局部给药一周后，兔子产生了耐受性。
