McCalden T A, Levy M
Department of Pharmacology, Liposome Technology Inc., Menlo Park, California 94025.
Experientia. 1990 Jul 15;46(7):713-5. doi: 10.1007/BF01939943.
The ability of liposomes composed of different kinds of phospholipid materials to adhere to the surface of the cornea was studied in the rabbit. The liposomes were labelled with tracer amounts of an I125-labelled phosphatidylethanolamine derivative and were instilled in 10 microliters drops onto the cornea. The retention of radioactivity was monitored. The results show that liposomes containing positively charged phospholipids are better retained than an albumin control. Thus, it may be possible to develop a drug delivery liposome system which would permit long-term sustained release of ophthalmic drugs onto the cornea.
在兔子身上研究了由不同种类磷脂材料组成的脂质体粘附于角膜表面的能力。脂质体用微量的碘125标记的磷脂酰乙醇胺衍生物进行标记，并以10微升的滴剂滴入角膜。监测放射性的保留情况。结果表明，含有带正电荷磷脂的脂质体比白蛋白对照保留得更好。因此，有可能开发一种药物递送脂质体系统，使眼科药物能够在角膜上长期持续释放。
