Subbammal S, Krishnamurthy D V, Tripathy S P, Venkataraman P
Bull World Health Organ. 1968;39(5):771-4.
Serial concentrations of pyrazinamide in 3 volunteers showed that increasing the dose from 22 mg/kg of body-weight to 66 mg/kg resulted in substantially higher serum concentrations of the drug and a longer period of coverage (at a concentration of 25 mug/ml). Similarly, in a study based on 6 tuberculous patients, increasing the dose of pyrazinamide from 66 mg/kg to 88 mg/kg led to appreciably higher concentrations in the serum. In neither series of tests was any acute hepatic toxicity observed. The findings suggest that it would be interesting to study the effect of doses of about 90 mg/kg of pyrazinamide in once-weekly regimens of chemotherapy for the treatment of tuberculosis.
3名志愿者体内吡嗪酰胺的系列浓度表明，将体重剂量从22mg/kg增加到66mg/kg会使药物的血清浓度显著升高，且覆盖时间延长（浓度为25μg/ml时）。同样，在一项基于6名结核病患者的研究中，将吡嗪酰胺剂量从66mg/kg增加到88mg/kg会使血清浓度明显升高。在这两组试验中均未观察到任何急性肝毒性。这些发现表明，研究在每周一次的结核病化疗方案中使用约90mg/kg吡嗪酰胺剂量的效果将是很有意思的。
