Savula M M, Smolenko M I, Romaniuk M D, Slivka Iu I
Probl Tuberk. 1990(11):25-8.
Different combinations of tuberculostatic drugs containing pyrazinamide were prescribed to 144 patients with pulmonary tuberculosis. In 3 months of treatment, bacterial excretion was observed in 89.7% of newly diagnosed patients and in 59% of cases with chronic forms of pulmonary tuberculosis. Side effects due to pyrazinamide were registered in 16.8% of the patients. In 2-3 months of therapy there were no differences traced in the condition of the liver, lipoid peroxidation or antioxidative activity as well as in a number of immunologic indices both in subjects receiving different combinations of antituberculous drugs, containing pyrazinamide, and in the control group of patients untreated with the drug.
对144例肺结核患者使用了含吡嗪酰胺的不同组合抗结核药物。治疗3个月时，新诊断患者中89.7%出现细菌排泄，慢性肺结核患者中59%出现细菌排泄。16.8%的患者出现了吡嗪酰胺引起的副作用。在治疗2 - 3个月时，接受含吡嗪酰胺的不同抗结核药物组合的患者与未使用该药物的对照组患者相比，在肝脏状况、脂质过氧化或抗氧化活性以及一些免疫指标方面均未发现差异。
