Canetti G, Fox W, Khomenko A, Mahler H T, Menon N K, Mitchison D A, Rist N, Smelev N A
Bull World Health Organ. 1969;41(1):21-43.
In a paper arising out of an informal international consultation of specialists in the bacteriology of tuberculosis held in 1961, an attempt was made to formulate criteria, and specify technical procedures, for reliable tests of sensitivity (the absolute-concentration method, the resistance-ratio method and the proportion method) to the 3 main antituberculosis drugs (isoniazid, streptomycin and p-aminosalicylic acid). Seven years later, a further consultation was held to review the latest developments in the field and to suggest how sensitivity tests might be put to practical use in tuberculosis control programmes. The participants reached agreement on how to define drug sensitivity and resistance, and stressed the importance of using a discrimination approach to the calibration of sensitivity tests. Their views are contained in the present paper, which also includes descriptions of the sensitivity tests used by the Medical Research Council of Great Britain for first- and second-line drugs (minimal inhibitory concentration and resistance-ratio methods), the two main variants of the proportion method developed by the Institut Pasteur, Paris, and a method for calibrating sensitivity tests.
在一篇源自1961年结核病细菌学专家非正式国际咨询会议的论文中，人们尝试制定标准并明确技术程序，用于对3种主要抗结核药物（异烟肼、链霉素和对氨基水杨酸）进行可靠的敏感性测试（绝对浓度法、耐药比法和比例法）。7年后，又举行了一次咨询会议，以回顾该领域的最新进展，并就如何在结核病控制项目中实际应用敏感性测试提出建议。与会者就如何定义药物敏感性和耐药性达成了一致，并强调了采用鉴别方法校准敏感性测试的重要性。他们的观点包含在本文中，本文还介绍了英国医学研究理事会用于一线和二线药物的敏感性测试方法（最低抑菌浓度法和耐药比法）、巴黎巴斯德研究所开发的比例法的两种主要变体，以及一种校准敏感性测试的方法。
