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胃黏膜弥漫性肥大(梅内特里耶病)与缺铁性贫血。

Diffuse hypertrophy of gastric mucosa (Menétrier's disease) and iron-deficiency anaemia.

作者信息

Singh A K, Cumaraswamy R C, Corrin B

出版信息

Gut. 1969 Sep;10(9):735-7. doi: 10.1136/gut.10.9.735.

DOI:10.1136/gut.10.9.735
PMID:5311583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1552981/
Abstract

A 23-year-old woman presented with intractable iron-deficiency anaemia. A barium meal showed widespread mucosal abnormalities in the stomach and massive mucosal hypertrophy was found at laparotomy. Repeated tests for occult blood were negative but gastrointestinal haemorrhage was confirmed by isotopic blood labelling. In the face of persistent anaemia and radiological progression, total gastrectomy was performed, since when a normal blood picture has been maintained. The excised stomach showed hyperplasia of all the mucosal elements, minimal inflammation, and no obvious bleeding point. Blood loss was attributed to diapedesis from a greatly increased capillary network.

摘要

一名23岁女性因顽固性缺铁性贫血前来就诊。钡餐检查显示胃部广泛的黏膜异常,剖腹手术时发现大量黏膜肥厚。多次潜血试验均为阴性,但同位素血液标记证实存在胃肠道出血。鉴于持续贫血且影像学表现进展,遂行全胃切除术,自那以后患者维持了正常的血象。切除的胃显示所有黏膜成分增生,炎症轻微,且无明显出血点。失血归因于大量增加的毛细血管网的渗漏。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e8/1552981/6909ca5c1ad5/gut00699-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e8/1552981/642fb14ecc63/gut00699-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e8/1552981/cd9e40946794/gut00699-0052-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e8/1552981/6909ca5c1ad5/gut00699-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e8/1552981/642fb14ecc63/gut00699-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e8/1552981/cd9e40946794/gut00699-0052-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80e8/1552981/6909ca5c1ad5/gut00699-0053-a.jpg

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1
Diffuse hypertrophy of gastric mucosa (Menétrier's disease) and iron-deficiency anaemia.胃黏膜弥漫性肥大(梅内特里耶病)与缺铁性贫血。
Gut. 1969 Sep;10(9):735-7. doi: 10.1136/gut.10.9.735.
2
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[Ménétrier's disease].[梅内特里耶病]
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引用本文的文献

1
Natural history of adult-onset Ménétrier's disease: Report of a case with 9-year follow-up.成人起病的梅内特里耶病的自然病史:一例9年随访报告。
Exp Ther Med. 2016 Jun;11(6):2462-2466. doi: 10.3892/etm.2016.3181. Epub 2016 Mar 23.
2
The diagnosis of Ménétrier's disease.梅内特里耶病的诊断。
Postgrad Med J. 1981 Sep;57(671):562-5. doi: 10.1136/pgmj.57.671.562.
3
Antral hypertrophic gastritis: a rare cause of iron deficiency.胃窦肥厚性胃炎:缺铁的罕见原因。

本文引用的文献

1
Giant hypertrophic gastritis simulating malignant disease.
Br J Surg. 1951 Nov;39(155):244-6. doi: 10.1002/bjs.18003915509.
2
Giant hypertrophic gastritis. A report of fourteen cases.巨大肥厚性胃炎。14例报告。
Gastroenterology. 1960 Aug;39:183-90.
3
Menetrier's disease. Spontaneous metamorphosis of giant hypertrophy of the gastric mucosa to atrophic gastritis.
Gastroenterology. 1967 Dec;53(6):953-60.
J Clin Pathol. 1985 Apr;38(4):390-2. doi: 10.1136/jcp.38.4.390.
4
Menetrier's disease presenting with deep venous thrombosis, iron deficiency anaemia and early evolution to atrophic gastritis.以深静脉血栓形成、缺铁性贫血并早期演变为萎缩性胃炎为表现的梅内特里耶病。
Ir J Med Sci. 1986 Feb;155(2):53-4. doi: 10.1007/BF02939997.
5
A clinicopathologic study of sex cases.性病例的临床病理研究。 (注:原文中“sex cases”表述有误,可能是“six cases”,若按正确的“six cases”翻译为“六例病例的临床病理研究” )
Ann Surg. 1977 Apr;185(4):456-61. doi: 10.1097/00000658-197704000-00015.