Davis J M, Gray G F, Thorbjarnarson B
Ann Surg. 1977 Apr;185(4):456-61. doi: 10.1097/00000658-197704000-00015.
Six patients with surgically treated Menetrier's disease are presented. Diffuse or focal cystic hyperplasia of mucous secreting epithelium of the fundus with antral sparing characterized the stomachs in all of these cases. In most instances the disorder was found during evaluation of non-specific complaints of pain, nausea and diarrhea. Only one patient had sufficient loss of albumin to produce server ankle edema and four of the others had below normal serum albumin levels without associated symptoms. One patient presented with life threatening bleeding from the hyperplastic mucosa. None of the patients had an associated endocrine neoplasm. All of the patients are living and without symptoms of disease for periods ranging from three to twelve years after resection of all or part of the hyperplastic mucosa. The rationale for surgical therapy in this condition is presented.
本文报告了6例接受手术治疗的梅内特里尔病患者。所有这些病例的胃部特征均为胃底黏液分泌上皮的弥漫性或局灶性囊性增生，胃窦未受累。在大多数情况下，该疾病是在评估疼痛、恶心和腹泻等非特异性症状时发现的。只有1例患者白蛋白严重丢失，导致严重的脚踝水肿，其他4例患者血清白蛋白水平低于正常，但无相关症状。1例患者出现增生性黏膜危及生命的出血。所有患者均未伴有内分泌肿瘤。所有患者在切除全部或部分增生性黏膜后，已存活3至12年，且无疾病症状。文中还介绍了针对这种情况进行手术治疗的理论依据。
