11-脱氧-16,16-三亚甲基前列腺素E1的前列腺素E拮抗剂活性
Prostaglandin E antagonist activity of 11-deoxy-16,16-trimethyleneprostaglandin E1.
作者信息
Birnbaum J E, Tolman E L
出版信息
Prostaglandins. 1979 Sep;18(3):349-57. doi: 10.1016/s0090-6980(79)80053-2.
PMID:531217
Abstract
11-Deoxy-16,16-trimethyleneprostaglandin E1 is a potent inhibitor of prostaglandin E-induced contractions of the gerbil colon. The antagonism is directed specifically against the prostaglandin E receptor and is not manifested when contractions are induced by either prostaglandin F2 alpha or acetylcholine.
摘要
11-脱氧-16,16-三亚甲基前列腺素E1是前列腺素E诱导沙鼠结肠收缩的强效抑制剂。这种拮抗作用是特异性针对前列腺素E受体的，当由前列腺素F2α或乙酰胆碱诱导收缩时则不表现出来。
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