前列腺素及其类似物 XIII（1）。dl-赤藓醇-16-甲氧基前列腺素的合成。
Prostaglandins and congeners XIII (1). The synthesis of dl-erythro-16-methoxyprostaglandins.
作者信息
Hallett W A, Wissner A, Grudzinskas C V, Partridge R, Birnbaum J E, Weiss M J
出版信息
Prostaglandins. 1977 Mar;13(3):409-15. doi: 10.1016/0090-6980(77)90021-1.
PMID:847242
Abstract
dl-Erythro-16-methoxy-PGE2, PGA2, PGF2alpha, 11-deoxy PGE1, and 11-deoxy PGF1alpha have been prepared via the cuprate conjugate addition procedure. These congeners are less potent than the parent prostaglandins as stimulators of isolated gerbil colon contractions and as bronchodilators in the guinea pig Konzett assay.
摘要
dl-赤式-16-甲氧基-PGE2、PGA2、PGF2α、11-脱氧PGE1和11-脱氧PGF1α已通过铜酸盐共轭加成法制备。在离体沙鼠结肠收缩刺激试验以及豚鼠Konzett试验中作为支气管扩张剂时，这些同系物的效力低于母体前列腺素。
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