PGH3的制备及其生化特性
Preparation and biochemical properties of PGH3.
作者信息
Smith D R, Weatherly B C, Salmon J A, Ubatuba F B, Gryglewski R J, Moncada S
出版信息
Prostaglandins. 1979 Sep;18(3):423-38. doi: 10.1016/s0090-6980(79)80061-1.
PMID:531219
Abstract
PGH3 was biosynthesised from all-cis-5,8,11,14,17-eicosapentaenoic acid (20:5 omega 3) by an acetone-pentane powder of ram seminal vesicles and its structure was confirmed by GLC-MS after its reduction to PGF 3 alpha. PGH3 was transformed by horse platelet microsomes to TXB3, and by aortic microsomes to delta 17-6-keto-PGF 1 alpha. The structures of these compounds were confirmed by GLC-MS.
摘要
PGH3由全顺式-5,8,11,14,17-二十碳五烯酸（20:5 ω-3）通过公羊精囊的丙酮-戊烷粉末生物合成，其结构在还原为PGF 3α后经气相色谱-质谱联用仪（GLC-MS）确认。PGH3被马血小板微粒体转化为TXB3，被主动脉微粒体转化为δ17-6-酮-PGF 1α。这些化合物的结构经GLC-MS确认。
Zotero 插件