牛痘病毒不可中和部分的研究。
Studies on the non-neutralizable fraction of vaccinia virus.
作者信息
Majer M, Link F
出版信息
Clin Exp Immunol. 1970 Aug;7(2):283-91.
Abstract
Unfiltered (containing aggregates) and filtered (monodisperse) vaccinia virus was investigated in a neutralization test. Ninety per cent of the virus population was found to be neutralized whereas 10% remained infective (non-neutralizable fraction). This non-neutralizable fraction consisted of infective virus antibody complexes (sensitized virus) which could be completely inactivated by anti-antibodies. There was a difference in the kinetics of neutralization between unfiltered and filtered virus but no difference in the formation of the non-neutralizable fraction. The mechanism of virus sensitization and some possible application of anti-antibodies are discussed.
摘要
在中和试验中研究了未过滤的（含有聚集体）和过滤的（单分散的）痘苗病毒。发现90%的病毒群体被中和，而10%仍具有感染性（不可中和部分）。这个不可中和部分由感染性病毒抗体复合物（致敏病毒）组成，其可被抗抗体完全灭活。未过滤病毒和过滤病毒在中和动力学上存在差异，但在不可中和部分的形成上没有差异。讨论了病毒致敏机制和抗抗体的一些可能应用。
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