各种抗淋巴细胞血清对迁移抑制因子（MIF）形成的抑制作用。

The inhibition of formation of migration inhibiting factor (MIF) by various antilymphocyte sera.

作者信息

Pekárek J, Svejcar J, Johanovský J

出版信息

Immunology. 1971 Jun;20(6):895-900.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455954/

Abstract

Antilymphocyte serum was prepared in several species and its effect on the production of migration inhibitory factor (MIF) studied. Antilymphocyte sera in dilutions as high as 1/3200 inhibited the liberation of MIF by sensitized lymphocytes in the presence of antigen. In contrast antipolymorph and antiglobulin sera were inactive. Antilymphocyte serum also blocked the formation of MIF when the lymphocytes were preincubated with ALS and then washed before the addition of antigen. The antilymphocyte serum and sera prepared against supernatants containing MIF did not block MIF activity by direct neutralization.

摘要

在多个物种中制备了抗淋巴细胞血清，并研究了其对迁移抑制因子（MIF）产生的影响。稀释至1/3200的抗淋巴细胞血清在有抗原存在的情况下可抑制致敏淋巴细胞释放MIF。相比之下，抗多形核白细胞血清和抗球蛋白血清则无活性。当淋巴细胞先用抗淋巴细胞血清预孵育，然后在加入抗原前洗涤时，抗淋巴细胞血清也会阻断MIF的形成。抗淋巴细胞血清和针对含有MIF的上清液制备的血清不会通过直接中和作用阻断MIF活性。

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引用本文的文献

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The production of migration inhibitory factor (MIF) in rabbit lymphocytes by other than immunological mechanism.兔淋巴细胞通过非免疫机制产生迁移抑制因子（MIF）。

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本文引用的文献

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An analysis of the multiplicity of the effects of antilymphocyte serum. A comparison with the action of other immunosuppressive agents in the cell-mediated immune response and non-specific inflammation.抗淋巴细胞血清作用多样性分析。与其他免疫抑制剂在细胞介导免疫反应和非特异性炎症中的作用比较。

Antibiot Chemother. 1969;15:267-94. doi: 10.1159/000386786.

2

Cell migration inhibition factor released by antigen from human peripheral lymphocytes.人外周淋巴细胞抗原释放的细胞迁移抑制因子。

Nature. 1968 Aug 17;219(5155):755-7. doi: 10.1038/219755a0.

3

Inhibition of cytotoxic lymphocytes by anti-lymphocytic serum.抗淋巴细胞血清对细胞毒性淋巴细胞的抑制作用。

Transplant Proc. 1969 Mar;1(1):420-3.

4

Studies on the mechanism of delayed type hypersensitivity in tissue cultures. XIV. Species nonspecificity of biologically active substances (migration inhibiting factor) released during the interaction of hypersensitive lymphocytes with antigen in vitro.组织培养中迟发型超敏反应机制的研究。十四。体外超敏淋巴细胞与抗原相互作用时释放的生物活性物质（迁移抑制因子）的种属非特异性。

Z Immunitatsforsch Allerg Klin Immunol. 1971;141(2):119-28.

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