Holdstock G, Eade O E, Isaacson P, Smith C L
Scand J Gastroenterol. 1979;14(6):717-20. doi: 10.3109/00365527909181943.
Endoscopic duodenal biopsies were taken from 27 patients with suspected coeliac disease and compared with intubation capsule jejunal biopsies. The specimens were reported without knowledge of the patients' names or symptoms. In 24 patients (89%), coeliac disease could either be diagnosed or excluded with 100% accuracy, despite the inability to orientate the biopsies correctly. Six biopsies were considered technically unsatisfactory, but only in three (11%) was it impossible to exclude coeliac disease. Duodenal biopsies were also taken from 118 consecutive patients attending for routine upper gastrointestinal endoscopy, and 1 patient with coeliac disease was discovered. We conclude that endoscopic duodenal biopsies are a reliable and worthwhile screening test for coeliac disease in certain patients attending for routine upper gastrointestinal endoscopy.
对27例疑似乳糜泻的患者进行了内镜下十二指肠活检，并与插管胶囊空肠活检进行了比较。标本报告时不知道患者的姓名或症状。在24例患者（89%）中，尽管活检标本无法正确定位，但乳糜泻的诊断或排除准确率达100%。6例活检标本在技术上被认为不满意，但只有3例（11%）无法排除乳糜泻。还对118例接受常规上消化道内镜检查的连续患者进行了十二指肠活检，发现1例乳糜泻患者。我们得出结论，对于某些接受常规上消化道内镜检查的患者，内镜下十二指肠活检是一种可靠且值得的乳糜泻筛查方法。
