Lawaetz O, Sivertsen Weis-Fogh U, Wandall H H
Scand J Gastroenterol. 1979;14(8):981-6.
For the elaboration of a formula estimating the reflux volume of duodenal secretion into the stomach, gastric and duodenal secretion have been studied during pentagastrin and secretin stimulation. In the stimulated gastric secretion the concentration of sodium varied with the secretion rate, whereas the concentration of chloride was nearly constant. The concentration of sodium in duodenal juice was constant, but the chloride concentration dropped significantly during secretin stimulation. Secretin induces duodenal reflux. When duodenal reflux occurs, a substantial amount of the sodium in gastric juice is attributable to intruding duodenal juice. The formula gives the duodenal reflux volume in 15-min samples on the basis of the sodium in gastric secretion and in the duodenal juice. A concentration of sodium in samples of gastric juice twice exceeding the concentration of sodium in maximally stimulated gastric secretion (8 +/- 2 mmol/l, mean +/- S.D.) may suggest 'contamination' of the samples with duodenal juice. The present formula allows for quantitative determination of this 'contamination.'
为了制定一个估算十二指肠分泌液反流至胃内的反流体积的公式，在五肽胃泌素和促胰液素刺激期间对胃液和十二指肠分泌液进行了研究。在刺激的胃液中，钠的浓度随分泌速率而变化，而氯的浓度几乎恒定。十二指肠液中钠的浓度是恒定的，但在促胰液素刺激期间氯的浓度显著下降。促胰液素可诱导十二指肠反流。当发生十二指肠反流时，胃液中大量的钠可归因于侵入的十二指肠液。该公式根据胃液和十二指肠液中的钠来计算15分钟样本中的十二指肠反流体积。胃液样本中钠的浓度两倍超过最大刺激胃液中钠的浓度（8±2 mmol/L，平均值±标准差）可能提示样本被十二指肠液“污染”。本公式可对这种“污染”进行定量测定。
