Effect of acid in the duodenal bulb on acid and pepsin responses to test meal in dogs.

Dogs were provided with innervated pouches of the fundic stomach and of the duodenal bulb. Gastric secretion was stimulated by a test meal. Bulbar perfusion with 0.1 N HCl profoundly ibhibited the secretion of acid. Also pepsin output and concentration of pepsin in gastric juice were reduced by bulbar acidification. The results may mean that reduction of the intrabulbar pH also plays a role in regulation of the secretion of pepsin from the stomach.