大鼠体内抗胆碱酯酶所致体温过低：其在肟类药物中枢效应研究中的实际应用
The anticholinesterase hypothermia in the rat: its practical application in the study of the central effectiveness of oximes.
作者信息
Meeter E, Wolthuis O L, van Benthem R M
出版信息
Bull World Health Organ. 1971;44(1-3):251-7.
Abstract
Cholinesterase inhibitors that can pass the blood-brain barrier produce hypothermia when injected intravenously in just sublethal doses. From a comparison of the hypothermia-reducing effects of five cholinesterase-reactivating oximes when injected intraperitoneally or subarachnoidally into rats pretreated with DFP or soman it was possible to distinguish central and peripheral actions of the oximes. The comparative efficacy of the five oximes and the effectiveness of cholinesterase inhibitors in producing hypothermia in other animal species, including man, are discussed.
摘要
能够透过血脑屏障的胆碱酯酶抑制剂，静脉注射仅亚致死剂量时就会产生体温过低。通过比较五种胆碱酯酶复活肟在腹腔内或蛛网膜下腔注射到用二异丙基氟磷酸酯（DFP）或梭曼预处理的大鼠体内时的降温效果，可以区分肟的中枢和外周作用。文中还讨论了这五种肟的相对疗效以及胆碱酯酶抑制剂在包括人类在内的其他动物物种中产生体温过低的有效性。
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