Merkelbach U, Burger A
Schweiz Med Wochenschr. 1979 Nov 3;109(42):1606-8.
A direct radioimmunoassay for human serum thyroglobulin (TG) has been developed. The lower limit of detection of the assay was 7.5 ng/ml. The serum values in normal subjects were between 0 and 44 ng/ml (n = 34, 21 female subjects, 13 male subjects). In 22 of the 34 subjects, TG was not detectable. The mean value of TG in a group of 19 subjects with multinodular goiter was 115.8 +/- 62.7 ng/ml (mean +/- SD). A group of 16 thyrotoxic individuals also had an elevated TG concentration (107 +/- 71 ng/ml). The serum TG levels in 6 patients with differentiated thyroid carcinoma with metastases were much more elevated than in any other clinical situation (3430 +/- 1100 ng/ml). In patients with thyroid cancer in clinical remission (n = 9), the TG levels were normal. In 2 patients with non-differentiated thyroid tumors, TG was not detectable. The major methodological problem in TG determination is the presence of anti-TG autoantibodies which may interfere with the radioimmunoassay.
已开发出一种用于检测人血清甲状腺球蛋白（TG）的直接放射免疫分析法。该分析法的检测下限为7.5 ng/ml。正常受试者的血清值在0至44 ng/ml之间（n = 34，其中21名女性受试者，13名男性受试者）。在34名受试者中的22名中，未检测到TG。一组19名患有结节性甲状腺肿的受试者的TG平均值为115.8 +/- 62.7 ng/ml（平均值 +/- 标准差）。一组16名甲状腺毒症患者的TG浓度也升高（107 +/- 71 ng/ml）。6名患有分化型甲状腺癌伴转移的患者的血清TG水平比任何其他临床情况都要高得多（3430 +/- 1100 ng/ml）。处于临床缓解期的甲状腺癌患者（n = 9）的TG水平正常。在2名患有未分化甲状腺肿瘤的患者中，未检测到TG。TG测定中的主要方法学问题是存在可能干扰放射免疫分析的抗TG自身抗体。
