Schneider A B, Ikekubo K
Ann Clin Lab Sci. 1979 May-Jun;9(3):230-5.
The concentration of thyroglobulin (TG) in the circulation can be measured by a sensitive, specific, convenient radioimmunoassay. TG is found in the circulation of virtually all normal subjects. It is present in elevated concentrations in patients with a wide variety of thyroid diseases including benign and malignant tumors, multinodular goiter, subacute thyroiditis, Graves' disease and others. At the present time, the most important clinical role of TG measurements is in the evaluation of patients who have been treated for thyroid cancer. As greater clinical correlation is obtained, the usefulness of TG determinations will increase. Anti-TG autoantibodies cause false results in the assay and present the major technical problem which needs to be resolved.
循环中甲状腺球蛋白（TG）的浓度可通过灵敏、特异且便捷的放射免疫测定法进行检测。实际上，在所有正常受试者的循环中均可发现TG。在患有多种甲状腺疾病（包括良性和恶性肿瘤、多结节性甲状腺肿、亚急性甲状腺炎、格雷夫斯病等）的患者中，TG浓度会升高。目前，TG检测最重要的临床作用在于对接受过甲状腺癌治疗的患者进行评估。随着临床相关性的增强，TG测定的实用性将会提高。抗TG自身抗体在检测中会导致错误结果，这是需要解决的主要技术问题。
