小鼠对母源不相容IgG 2a球蛋白的耐受性与免疫性。
Tolerance and immunity to maternally derived incompatible IgG 2a -globulin in mice.
作者信息
Warner N L, Herzenberg L A
出版信息
J Exp Med. 1970 Sep 1;132(3):440-7. doi: 10.1084/jem.132.3.440.
Progeny mice were confronted with maternal gamma-globulin of a different allotype by either back-cross mating, intercross mating, or by foster nursing. In all cases, many mice subsequently produced alloantibodies directed against the incompatible maternal type of IgG(2a)-globulin. In one series of experiments, immunologic tolerance to the maternally derived gamma-globulin was demonstrated to exist in the period before formation of spontaneous antibody. The state of tolerance was then lost, unless maintenance injections of foreign gamma-globulin were given. These studies demonstrate in a natural situation that maternally derived foreign proteins can first induce a state of immunological tolerance which is followed, after disappearance of the antigen, by a state of immunity. As such, this parallels the experimental induction of tolerance to foreign proteins by neonatal injections.
通过回交、杂交或寄养哺乳，将子代小鼠暴露于不同同种异型的母体γ球蛋白。在所有情况下，许多小鼠随后产生了针对不相容母体类型IgG(2a)球蛋白的同种抗体。在一系列实验中，已证明在自发抗体形成之前的时期存在对母体来源γ球蛋白的免疫耐受性。然后，除非给予维持注射外源γ球蛋白，否则耐受性状态会丧失。这些研究在自然情况下表明，母体来源的外源蛋白首先可诱导免疫耐受状态，在抗原消失后，继之以免疫状态。因此，这与通过新生期注射对外源蛋白诱导耐受性的实验情况相似。
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