Feroz M
Bull World Health Organ. 1971;45(6):795-804.
The penetration of (14)C-labelled malathion was found to be similar in two bedbug strains, of which one was susceptible and the other moderately resistant to a range of organophosphorus insecticides. The latter strain was especially resistant to malathion and fenchlorphos, but was not resistant to organophosphates or (significantly) to organochlorine insecticides. There was no difference in acetylcholinesterase activity or sensitivity, or in total esterase activity (using 1- or 2-naphthyl acetates as substrates). In vitro experiments on malathion metabolism showed about 17% greater degradation in the resistant strain, demethyl malathion and malathion diacid being the main products.
研究发现，（14）C 标记的马拉硫磷在两种臭虫品系中的渗透情况相似，其中一种对一系列有机磷杀虫剂敏感，另一种则具有中等抗性。后一种品系对马拉硫磷和皮蝇磷具有特别抗性，但对有机磷酸酯类或（显著地）对有机氯杀虫剂不具抗性。在乙酰胆碱酯酶活性或敏感性以及总酯酶活性（以 1 - 萘基乙酸或 2 - 萘基乙酸为底物）方面没有差异。关于马拉硫磷代谢的体外实验表明，抗性品系中的降解率高出约 17%，主要产物为去甲基马拉硫磷和马拉硫磷二酸。
