Natanson A O, Grigor'eva L V
Vopr Med Khim. 1971 Jul-Aug;17(4):411-4.
A method allowing simultaneous assay of the tissue content of three forms of vitamin A (alcohol, ester, aldehyde) was applied for investigation of these forms in liver, kidneys, adrenals and blood plasma in rats with experimental hyper- and hypothyreosis. It is established that compared to control rats, hyperthyroid animals show increased content of vitamin A-alcohol in adrenals with simultaneous decrease in liver of vitamin A-alcohol and especially of its ester. It is supposed that these changes are directly induced by the action of thyroxine on vitamin A metabolism in tissues. During hyperthyreosis, content of vitamin A (alcohol and ester) in liver sharply falls and there is a tendency towards its decrease on blood plasma and adrenals. Approximately the same ratio of alcohol and ester of vitamin A in kidneys indicated its intensive metabolism in this organ. As judged from the absence of changes in content of vitamin A-aldehyde in organs, activation as well as suppression of the function of thyroid gland apparently is not followed by an increase in oxidative transformation of vitamin A in tissues.
一种可同时测定三种形式维生素A（醇、酯、醛）组织含量的方法，被用于研究实验性甲状腺功能亢进和减退大鼠的肝脏、肾脏、肾上腺及血浆中的这些形式。结果表明，与对照大鼠相比，甲状腺功能亢进动物的肾上腺中维生素A-醇含量增加，同时肝脏中维生素A-醇尤其是其酯的含量降低。推测这些变化是由甲状腺素对组织中维生素A代谢的直接作用引起的。甲状腺功能亢进期间，肝脏中维生素A（醇和酯）的含量急剧下降，血浆和肾上腺中也有下降趋势。肾脏中维生素A的醇和酯比例大致相同，表明该器官中其代谢活跃。从器官中维生素A-醛含量无变化判断，甲状腺功能的激活以及抑制显然并未伴随组织中维生素A氧化转化的增加。
