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[肿瘤患者的胃肠外蛋白质替代]

[Parenteral protein substitution in tumor patients].

作者信息

Seifart W, Blumberg H H

出版信息

Z Exp Chir. 1979 Aug;12(4):232-9.

PMID:532242
Abstract

The substitution of protein deficiency by a standardized dosage of 48...60 g human albumin and 160 g amino acids divided over 4 days is hardly less effective as the substitution by the same dosage of amino acids alone. Insignificant differences of the preoperative und postoperative effect of the substitution therapy in patients with tumors of esophagus or stomach and colorectal cancer are discussed and seem to confirm the conclusion to perform the parenteral substitution of protein deficiency economical better only by the administration of amino acid solutions. The additional administration of non-protein calories in the meaning of parenteral nutrition seems to be dispensable if the simultaneous enteral alimentation satisfies these requirements. The relative substitution dosage of amino acids should not fall below 2,5 g . kg-1 divided over 4 days.

摘要

采用48……60克人白蛋白和160克氨基酸分4天给予的标准化剂量来替代蛋白质缺乏,其效果与仅用相同剂量的氨基酸替代相比,几乎没有差别。文中讨论了食管或胃癌及结直肠癌患者替代疗法术前和术后效果的微小差异,这似乎证实了仅通过给予氨基酸溶液来更经济地进行蛋白质缺乏的胃肠外替代的结论。如果同时进行肠内营养能满足这些需求,那么胃肠外营养意义上的非蛋白质热量的额外给予似乎是不必要的。氨基酸的相对替代剂量在4天内不应低于2.5克·千克-1。

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