Weppelmann B, Oberheuser F
Zentralbl Gynakol. 1979;101(15):945-9.
Sandwich radio-immune assay was used before, parallel with as well as following surgical and radiation therapies on 73 patients in a follow-up check for an assessment of the clinical value of CEA im adenocarcinoma of the uterine corpus. CEA levels were increased in only 17 per cent of all cases. The strongest drops in CEA levels in correlation with patients' clinical response to therapy were recorded from those probands who had undergone surgery followed by Co60 irradiation. While CEA determination is, generally, recommended for monitoring of therapy and for the detection of recurrent corpus carcinomas, only pathological CEA levels should be considered as being relevant to clinical action, since the rate of false negative values has been as high as 34 per cent.
之前采用夹心放射免疫测定法,在73例患者接受手术和放射治疗前、治疗期间及治疗后进行随访检查,以评估癌胚抗原(CEA)在子宫体腺癌中的临床价值。在所有病例中,CEA水平仅在17%的病例中升高。与患者对治疗的临床反应相关的CEA水平下降最为明显的是那些先接受手术然后接受钴60照射的受试者。虽然一般建议测定CEA以监测治疗和检测复发性子宫体癌,但只有病理性CEA水平才应被视为与临床行动相关,因为假阴性率高达34%。