[Regeneration of defects in a small portion of the urinary bladder mucosa in experiments with guinea pigs].

Regeneration of the vesical mucosa begins from the remains of the bladder at the trigonum and urethra, and the author studied this regeneration in 30 rats. Epithelial regeneration began on the third day after formation of the defect. On the fifth day the entire defect was covered with transitional epithelium whose thickness did not exceed 1--2 cell layers. During the fifth week regeneration was complete. This experiment confirms the claim of Baker et al. the regeneration of the mucossa of the urinary bladder (except for the remaining mucosa of the trigonum and urethra) occurs via differentiation of pluripotential mesenchyme cells into transitional epithelium. During the experiment, the rats were given garamycin prophylactically. The very short regeneration time was probably due to the absence of any inflammatory process.