Wishnow K I, Johnson D E, Grignon D J, Cromeens D M, Ayala A G
Department of Urology, University of Texas M. D. Anderson Cancer Center, Houston.
J Urol. 1989 Jun;141(6):1476-9. doi: 10.1016/s0022-5347(17)41350-4.
To study the site of origin of epithelial regeneration in the urinary bladder after surgical denudation, we completely obliterated the bladder mucosa in 17 dogs, using the neodymium: YAG laser. Bladder-mapping studies showed that the regenerating cells arose from the epithelium of the terminal ureters and urethra. Experimental construction of isolated bladder pouches confirmed these findings and demonstrated that urine flow was not essential for reepithelialization. These results are relevant to the treatment of patients with multifocal carcinoma in situ of the bladder. Although the entire bladder can be denuded successfully, the studies demonstrate that the procedure might fail if the sources of epithelial regrowth, the distal ureters and urethra, contain untreated carcinoma in situ.
为研究手术剥脱后膀胱上皮再生的起源部位，我们使用钕：钇铝石榴石激光完全去除了17只狗的膀胱黏膜。膀胱定位研究表明，再生细胞起源于输尿管末端和尿道的上皮。孤立膀胱袋的实验构建证实了这些发现，并表明尿液流动对于重新上皮化并非必不可少。这些结果与膀胱多灶性原位癌患者的治疗相关。尽管整个膀胱可以成功剥脱，但研究表明，如果上皮再生的来源，即远端输尿管和尿道，含有未经治疗的原位癌，该手术可能会失败。
