Morishita H, Nakago K, Ii K, Hashimoto T, Kawamoto M, Tanaka T, Higuchi K, Miyauchi Y, Ozasa T
Acta Endocrinol (Copenh). 1979 Dec;92(4):577-84. doi: 10.1530/acta.0.0920577.
Five day old female rats were administered either 500 micrograms clomiphene citrate or propylene glycol. Vaginal opening occurred significantly earlier in the clomiphene treated group as compared with the control group. Clomiphene treated rats showed permanent sterility associated with anovulatory vaginal cycles in which the stage of vaginal cornification predominated. Furthermore, clomiphene treated rats exhibited a high incidence of pyosalpinx (or oviductal abscess). The possible mechanisms responsible for the anovulatory sterility and the pyosalpinx induced by neonatal clomiphene treatment are discussed.
给5日龄雌性大鼠分别注射500微克枸橼酸氯米芬或丙二醇。与对照组相比，氯米芬治疗组的阴道开口明显提前出现。氯米芬治疗的大鼠表现出永久性不育，伴有以阴道角化阶段为主的无排卵性阴道周期。此外，氯米芬治疗的大鼠输卵管积脓（或输卵管脓肿）的发生率很高。本文讨论了新生大鼠氯米芬治疗导致无排卵性不育和输卵管积脓的可能机制。
