Birkenfeld A, Weber-Benndorf M, Mootz U, Beier H M
Ann N Y Acad Sci. 1985;442:153-67. doi: 10.1111/j.1749-6632.1985.tb37516.x.
The effect of clomiphene on the functional morphology of the uterine and oviductal mucosa was studied in rabbits by means of light and electron microscopy (SEM and TEM). Tissues were obtained from mature nulliparous animals receiving subcutaneous doses ranging from 0.01-10 mg/kg per day. In all cases the effects were evaluated 2 days after termination of treatment. With 2 and 10 mg, effects were studied up to 12 and 7 days, respectively. Normally appearing oviductal and endometrial tissues, corresponding to various stages of the cycle, were observed with doses up to 5 mg. However, a burst of cellular secretory activity becomes evident with the administration of higher doses. Apical protrusions or cytoplasmic portions seem to be extruded, and draw attention. These cytologic events are concentrated near gland openings in the endometrium and can be seen abundantly among cilia of oviductal cells. Other ultrastructural changes are evident as well. These histologic changes may reflect nonsynchronous cellular activities which in turn interfere with oviductal and endometrial functions before implantation.
通过光学显微镜以及电子显微镜（扫描电子显微镜和透射电子显微镜）研究了克罗米酚对兔子宫和输卵管黏膜功能形态的影响。组织取自皮下注射剂量为每天0.01 - 10毫克/千克的成熟未孕动物。在所有情况下，均在治疗结束后2天评估效果。对于2毫克和10毫克的剂量，分别在给药后12天和7天进行效果研究。使用剂量高达5毫克时，观察到外观正常的输卵管和子宫内膜组织，其对应于月经周期的各个阶段。然而，给予更高剂量时，细胞分泌活动会突然增强。顶端突起或细胞质部分似乎被挤出，引人注意。这些细胞学变化集中在子宫内膜腺体开口附近，并且在输卵管细胞的纤毛之间大量可见。其他超微结构变化也很明显。这些组织学变化可能反映了细胞活动的不同步，进而在着床前干扰输卵管和子宫内膜的功能。
