针对I区编码决定簇的细胞毒性T淋巴细胞的诱导：小鼠中第三个组织相容性位点的体外证据。
Induction of cytotoxic T lymphocytes against I-region-coded determinants: in vitro evidence for a third histocompatibility locus in the mouse.
作者信息
Wagner H, Götze D, Ptschelinzew L, Röllinghoff M
出版信息
J Exp Med. 1975 Dec 1;142(6):1477-87. doi: 10.1084/jem.142.6.1477.
Abstract
Determinants controlled by the I region of the murine H-2 complex provoked the generation of cytotoxic T lymphocytes (CTL) in both a secondary and primary mixed lymphocyte culture. The stimulating determinants appeared to be controlled by loci within the I-A subregion. The target antigens of the CTL generated were present on both lipopolysaccharide- and concanavalin-induced blast lymphocytes, but were barely detectable on phytohemagglutinin-induced blast cells. The stimulating capacity for CTL induction of a complete H-2 complex incompatibility by far exceeded the sum of H-2D/K-region and I-region incompatibility, respectively.
摘要
由小鼠H-2复合体I区控制的决定簇在二次和初次混合淋巴细胞培养中均可激发细胞毒性T淋巴细胞（CTL）的产生。刺激决定簇似乎受I-A亚区内基因座的控制。所产生的CTL的靶抗原存在于脂多糖和伴刀豆球蛋白诱导的母细胞样淋巴细胞上，但在植物血凝素诱导的母细胞上几乎检测不到。就CTL诱导而言，完全的H-2复合体不相容性的刺激能力远远超过H-2D/K区和I区不相容性分别产生的刺激能力之和。
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Induction of cytotoxic T lymphocytes against I-region-coded determinants: in vitro evidence for a third histocompatibility locus in the mouse.针对I区编码决定簇的细胞毒性T淋巴细胞的诱导：小鼠中第三个组织相容性位点的体外证据。
J Exp Med. 1975 Dec 1;142(6):1477-87. doi: 10.1084/jem.142.6.1477.
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Cytotoxic T lymphocytes specific for I region determinants do not require interactions with H-2K or D gene products.针对I区决定簇的细胞毒性T淋巴细胞不需要与H-2K或D基因产物相互作用。
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