Małecki I, Borkowska B, Wegrzyn I
Acta Physiol Pol. 1979 Sep-Dec;30(5-6):649-56.
The anti-ulcer activity of three different doses (1/10, 1/30 and 1/90 of LD50) of imipramine, amitryptyline, chlorpromazine, amphetamine, ephedrine, chlordiazepoxide and meprobamate was studied in two types of stress-produced gastric ulcers in rats. It was found that these drugs given in doses of 1/10 or 1/30 LD50 inhibited in the same degree the development of gastric ulcer-produced by the method of Senay, in spite of differences in their psychotropic activity. On the other hand, when the method of Rossi was used for ulcer production the ulcer-preventing activity of these drugs has been varied. Thymoleptics were most effective and ataractics least effective against ulcers produced by the method of Rossi.
研究了三种不同剂量（分别为半数致死量的1/10、1/30和1/90）的丙咪嗪、阿米替林、氯丙嗪、苯丙胺、麻黄碱、氯氮卓和甲丙氨酯对大鼠两种应激性胃溃疡的抗溃疡活性。结果发现，尽管这些药物的精神活性有所不同，但以1/10或1/30半数致死量给药时，它们对塞奈法所致胃溃疡的发展具有相同程度的抑制作用。另一方面，当采用罗西法诱导溃疡时，这些药物的抗溃疡活性有所不同。抗抑郁药对罗西法所致溃疡最为有效，而安定药则最无效。
