Fung W P, Papadimitriou J M
Am J Gastroenterol. 1979 Nov;72(5):522-7.
The effect of prostaglandin E2 (PGE2) and 15(R)15 methyl prostaglindin E2 (15(R)15 PGE2) on the gastric parietal cell was studied in seven and eight dogs, respectively. Another four dogs were used as controls. Gastric biopsies were examined by the electron microscope and the secretory activity of the parietal cells was assessed by morphometrically estimating the proportion of the parietal cell cytoplasm occupied by tubulovesicles as well as the ratio of extramitochondrial cytoplasm:mitochondria. Both 15(R)15 PGE2 and PGE2 increased the latter one hour after administration but only 15(R)15 PGE2 increased the proportion of tubulovesicles. The data suggest that secretory activity of parietal cells is impaired, especially after treatment with 15(R)15 GE2.
分别在7只和8只狗身上研究了前列腺素E2（PGE2）和15（R）15甲基前列腺素E2（15（R）15 PGE2）对胃壁细胞的作用。另外4只狗用作对照。通过电子显微镜检查胃活检组织，并通过形态计量学估计微管泡所占胃壁细胞质的比例以及线粒体外细胞质与线粒体的比例来评估壁细胞的分泌活性。15（R）15 PGE2和PGE2在给药后1小时均增加了后者，但只有15（R）15 PGE2增加了微管泡的比例。数据表明，壁细胞的分泌活性受损，尤其是在用15（R）15 GE2治疗后。
