从链球菌中分离出的一种红细胞致敏物质及其特性
Separation and properties of a red cell sensitizing substance from streptococci.
作者信息
Moskowitz M
出版信息
J Bacteriol. 1966 Jun;91(6):2200-4. doi: 10.1128/jb.91.6.2200-2204.1966.
Abstract
Moskowitz, Merwin (Purdue University, Lafayette, Ind.). Separation and properties of a red cell sensitizing substance from streptococci. J. Bacteriol. 91:2200-2204. 1966.-An antigen that binds onto red cells and causes them to be agglutinated by antiserum was separated from streptococci. Various procedures to extract the antigen from streptococci were investigated, and the greatest amount of antigen was obtained by extraction of cells with a phenol-water mixture. The reaction of the antigen with red cells was shown to be reversible by use of the Ashby mixed agglutination technique. The antigen also combines with a number of different tissues, and it was demonstrated that the antigen could be transferred from red cells to tissues and vice versa. An hypothesis is presented on the basis of these findings which suggests a possible role for this antigen in the etiology of rheumatic fever.
摘要
莫斯科维茨，默文（普渡大学，印第安纳州拉斐特）。从链球菌中分离出的一种红细胞致敏物质及其特性。《细菌学杂志》91:2200 - 2204。1966年。——从链球菌中分离出一种能结合到红细胞上并使其被抗血清凝集的抗原。研究了从链球菌中提取该抗原的各种方法，用酚 - 水混合物提取细胞获得了最大量的抗原。通过阿什比混合凝集技术表明该抗原与红细胞的反应是可逆的。该抗原还能与多种不同组织结合，并且证明抗原可以从红细胞转移到组织，反之亦然。基于这些发现提出了一个假说，提示该抗原在风湿热病因学中可能起的作用。
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