Cloarec L, Durou M R, Legras B, Esvant J Y
Ann Nutr Aliment. 1979;33(3):385-93.
The Moore's hypothesis concerning a relationship between the metabolism of copper and that of vitamin A led us to consider a possible relationship between this vitamin and ceruloplasmin, the carrier protein for copper. Experiments were carried out on Sprague-Dawley rats. The ceruloplasmin level of control animals and vitamin A - deficient rats was determined An average increase between 22 and 33% was observed in the animals with vitamin A deficiency, the highest levels being observed in the females. These results are in agreement with Peterson's previous work. A second type of experiment was carried out to confirm these results. The rats were raised in a copper-deficient diet and the vitamin A level was regularly determined. In these conditions serum and liver levels of vitamin A are normal and do not vary, ceruloplasmin level is zero; however apoceruloplasmin is still being synthetized : Nevertheless at the ultime state of the deficiency vitamin A level decreases while apoceruloplasmin increases. These results raise the following question. Could the relationship between ceruloplasmin and vitamin A be possibly due to an inflammatory state in vitamin A deficient rats. In this respect a third series of experiments were undertaken and are in progress; the vitamin A and ceruloplasmin levels are regularly determined.
摩尔关于铜代谢与维生素A代谢之间关系的假说，促使我们去思考这种维生素与铜蓝蛋白（铜的载体蛋白）之间可能存在的关系。实验以斯普拉格-道利大鼠为对象展开。测定了对照动物和维生素A缺乏大鼠的铜蓝蛋白水平。在维生素A缺乏的动物中观察到平均升高了22%至33%，雌性动物的水平最高。这些结果与彼得森之前的研究一致。进行了第二类实验以证实这些结果。用缺铜饮食饲养大鼠，并定期测定维生素A水平。在这些条件下，血清和肝脏中的维生素A水平正常且无变化，铜蓝蛋白水平为零；然而脱辅基铜蓝蛋白仍在合成：不过在缺乏的最终状态下，维生素A水平下降而脱辅基铜蓝蛋白增加。这些结果引发了以下问题。铜蓝蛋白与维生素A之间的关系是否可能归因于维生素A缺乏大鼠的炎症状态？在这方面，已开展并正在进行第三系列实验；定期测定维生素A和铜蓝蛋白水平。
