Favaro R M, Silva H C, Vannucchi H
Division of Nutrition, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Int J Vitam Nutr Res. 1994;64(2):98-103.
The objective of the present paper was to study the interaction of Neomycin and aluminium hydroxide with vitamin A in terms of the effect of these drugs on the bioavailability of vitamin A in the rat. Bioavailability was determined on the basis of the effects of the drugs on growth and on the plasma and hepatic levels of the vitamin. Vitamin A deficient animals were used in assay 1 and normal animals in assay 2. In each assay the animals were divided into 3 groups: one received Neomycin sulfate (0.1% in the diet), the second received aluminium hydroxide (0.05% in the diet) and the third (control) received no drug. Each of these three groups was subdivided into two groups receiving two different concentrations of vitamin A palmitate. The bioavailability of vitamin A was estimated by the parallel line method from the concentration of vitamin A in the diet and in the liver of the animals. No significant differences in growth or plasma retinol levels were observed between the groups of animals studied in assays 1 and 2. Total vitamin A concentration in the liver of the animals which received Neomycin was lower (p < 0.05) than that observed in the controls. Neomycin reduced the bioavailability of vitamin A by 13.9% (maximum, 18.1% and minimum, 9.6%) in assay 1 and by 13.5% (maximum, 17.7% and minimum, 9.3%) in assay 2. Aluminium hydroxide at the level tested did not affect the bioavailability of vitamin A.
本文的目的是研究新霉素和氢氧化铝与维生素A的相互作用，具体是考察这些药物对大鼠体内维生素A生物利用度的影响。生物利用度是根据药物对生长以及维生素在血浆和肝脏中的水平的影响来确定的。实验1使用维生素A缺乏的动物，实验2使用正常动物。在每个实验中，动物被分为3组：一组接受硫酸新霉素（饲料中含0.1%），第二组接受氢氧化铝（饲料中含0.05%），第三组（对照组）不接受药物。这三组中的每一组又被细分为两组，分别接受两种不同浓度的棕榈酸视黄酯。通过平行线法，根据动物饲料和肝脏中维生素A的浓度来估算维生素A的生物利用度。在实验1和实验2中所研究的动物组之间，未观察到生长或血浆视黄醇水平有显著差异。接受新霉素的动物肝脏中的总维生素A浓度低于对照组（p < 0.05）。在实验1中，新霉素使维生素A的生物利用度降低了13.9%（最高为18.1%，最低为9.6%），在实验2中降低了13.5%（最高为17.7%，最低为9.3%）。在所测试水平的氢氧化铝不影响维生素A的生物利用度。
