Nagasue N, Kanashima R, Inokuchi K
Ann Chir Gynaecol. 1979;68(4):137-42.
The aim of the present investigation was to determine whether pharmacological doses of corticosteroid can be used safely in the treatment of haemorrhagic shock during major hepatic resection. Following two-thirds hepatectomy in the rat the administration of dexamethasone, 4 mg/kg of body weight, produced higher morbidity and mortality compared with that in the control groups. This was considered to be mainly due to substantial suppression and retardation of liver regeneration. In addition, the steroid therapy exaggerated the degree and time of liver steatosis with marked elevation of serum fatty acid, triglyceride, phospholipid, and cholesterol concentrations. It appears therefore that it would be very hazardous to treat haemorrhagic shock as a result of major hepatic resection with pharmacological doses of corticosteroids.
本研究的目的是确定药理学剂量的皮质类固醇是否可安全用于治疗大肝切除术中的失血性休克。大鼠三分之二肝切除术后，给予地塞米松4mg/kg体重，与对照组相比，发病率和死亡率更高。这主要被认为是由于肝再生受到显著抑制和延迟。此外，类固醇治疗加重了肝脂肪变性的程度和时间，血清脂肪酸、甘油三酯、磷脂和胆固醇浓度显著升高。因此，用药理学剂量的皮质类固醇治疗大肝切除引起的失血性休克似乎非常危险。
