Strecker W, Silz S, Salem A, Ruhenstroth-Bauer G
Horm Metab Res. 1980 Nov;12(11):604-8. doi: 10.1055/s-2007-999210.
The factor(s) which trigger the proliferation of liver cells after partial hepatectomy in rats are not yet known with certainty. A series of specific and/or non-specific substances are said to effect the proliferation of liver cells, but metabolic changes after partial hepatectomy possibly also act as a contributory causative factor in the stimulation of those substances. In order to define this question more clearly the changes in the serum concentrations of the following metabolites in the course of time after partial hepatectomy were determined: free fatty acids, cholesterol, triglycerides, glucose, free amino acids and total protein. A reduction in the serum concentrations of some fatty acids and of glucose, and an increase in that of the free amino acids, was observed shortly after partial hepatectomy. The increase in the plasma concentration of immunoreactive glucagon after partial hepatectomy is thus explained and appears not to be of decisive significance for the stimulation of liver cell proliferation after partial hepatectomy.
大鼠部分肝切除术后触发肝细胞增殖的因素尚未完全明确。据说一系列特异性和/或非特异性物质会影响肝细胞的增殖，但部分肝切除术后的代谢变化可能也是刺激这些物质产生的一个促成因素。为了更清楚地界定这个问题，测定了部分肝切除术后不同时间血清中以下代谢物浓度的变化：游离脂肪酸、胆固醇、甘油三酯、葡萄糖、游离氨基酸和总蛋白。部分肝切除术后不久，观察到一些脂肪酸和葡萄糖的血清浓度降低，游离氨基酸的血清浓度升高。部分肝切除术后免疫反应性胰高血糖素血浆浓度的升高由此得到解释，且似乎对部分肝切除术后肝细胞增殖的刺激作用不具有决定性意义。
