慢性血液透析患者静脉注射哌拉西林的药代动力学
Pharmacokinetics of intravenous piperacillin in patients undergoing chronic hemodialysis.
作者信息
Francke E L, Appel G B, Neu H C
出版信息
Antimicrob Agents Chemother. 1979 Dec;16(6):788-91. doi: 10.1128/AAC.16.6.788.
Abstract
The pharmacokinetic properties of piperacillin, a piperazine derivative of ampicillin, were determined in seven patients with creatinine clearances less than 7 ml/min who were undergoing chronic, intermittent hemodialysis. A two-compartment linear model was used to analyze the data. Mean elimination half-life was 1.26 +/- 0.1 h; the mean elimination constant was 0.95 +/- 0.08 h-1; the mean volume of distribution was 0.16 +/- 0.02 liters/kg of body weight; the mean volume of the central compartment was 0.10 +/- 0.01 liters/kg of body weight; and the mean clearance was 0.09 +/- 0.01 liters/h per kg of body weight. Mean elimination half-life while off dialysis of 2.1 h.
摘要
哌拉西林是氨苄西林的哌嗪衍生物，对7例肌酐清除率低于7 ml/min且正在接受慢性间歇性血液透析的患者测定了其药代动力学特性。采用二室线性模型分析数据。平均消除半衰期为1.26±0.1小时；平均消除常数为0.95±0.08 h⁻¹；平均分布容积为0.16±0.02升/千克体重；中央室平均容积为0.10±0.01升/千克体重；平均清除率为0.09±0.01升/小时·千克体重。透析间期的平均消除半衰期为2.1小时。
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