嗜麦芽窄食单胞菌对单一及联合抗菌药物的敏感性
Susceptibility of Pseudomonas maltophilia to antimicrobial agents, singly and in combination.
作者信息
Felegie T P, Yu V L, Rumans L W, Yee R B
出版信息
Antimicrob Agents Chemother. 1979 Dec;16(6):833-7. doi: 10.1128/AAC.16.6.833.
Abstract
Pseudomonas maltophilia is resistant to most of the commonly used antimicrobial agents including those active against Pseudomonas aeruginosa. The susceptibility of 14 clinical isolates of P. Maltophilia to 18 antimicrobial agents was determined by broth dilution testing. All organisms were susceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), minocycline, and LY127935. A total of 87 and 79% of the organisms were susceptible in vitro to colistin and chloramphenicol, respectively. With the exception of sisomicin, the organisms were resistant to the aminoglycosides. Of 21 combinations of antimicrobials examined for synergy, only the combination of TMP-SMZ with carbenicillin was consistently (86%) synergistic in vitro. Supplementation of the testing media with calcium and magnesium increased the minimal inhibitory concentrations for the aminoglycosides, the penicillins, and TMP-SMZ against P. maltophilia.
摘要
嗜麦芽窄食单胞菌对大多数常用抗菌药物耐药，包括那些对铜绿假单胞菌有效的药物。通过肉汤稀释试验测定了14株嗜麦芽窄食单胞菌临床分离株对18种抗菌药物的敏感性。所有菌株对甲氧苄啶-磺胺甲恶唑（TMP-SMZ）、米诺环素和LY127935敏感。分别有87%和79%的菌株在体外对黏菌素和氯霉素敏感。除西索米星外，这些菌株对氨基糖苷类耐药。在所检测的21种抗菌药物联合用药的协同作用中，只有TMP-SMZ与羧苄西林的联合用药在体外始终表现出协同作用（86%）。在测试培养基中添加钙和镁会增加氨基糖苷类、青霉素类和TMP-SMZ对嗜麦芽窄食单胞菌的最低抑菌浓度。
相似文献
1
Susceptibility of Pseudomonas maltophilia to antimicrobial agents, singly and in combination.嗜麦芽窄食单胞菌对单一及联合抗菌药物的敏感性
Antimicrob Agents Chemother. 1979 Dec;16(6):833-7. doi: 10.1128/AAC.16.6.833.
2
In vitro sensitivity of Salmonella to ten antimicrobial agents including sulfamethoxazole and trimethoprim, alone and in combination.沙门氏菌对包括磺胺甲恶唑和甲氧苄啶在内的十种抗菌药物单独及联合使用时的体外敏感性。
Antimicrob Agents Chemother. 1973 Nov;4(5):555-9. doi: 10.1128/AAC.4.5.555.
3
Synergistic interaction in vitro with use of three antibiotics simultaneously against Pseudomonas maltophilia.体外同时使用三种抗生素对嗜麦芽窄食单胞菌的协同相互作用。
J Infect Dis. 1980 Oct;142(4):602-7. doi: 10.1093/infdis/142.4.602.
4
Susceptibility of Stenotrophomonas maltophilia clinical strains in China to antimicrobial combinations.中国嗜麦芽窄食单胞菌临床菌株对抗菌药物联合使用的敏感性
J Chemother. 2014 Oct;26(5):282-6. doi: 10.1179/1973947814Y.0000000168. Epub 2014 Mar 4.
5
In vitro susceptibility of Pseudomonas species to carbenicillin and trimethoprim-sulfamethoxazole.假单胞菌属对羧苄青霉素和甲氧苄啶-磺胺甲恶唑的体外敏感性。
J Clin Microbiol. 1985 Sep;22(3):465-6. doi: 10.1128/jcm.22.3.465-466.1985.
6
Activity of Cefiderocol Alone and in Combination with Levofloxacin, Minocycline, Polymyxin B, or Trimethoprim-Sulfamethoxazole against Multidrug-Resistant Stenotrophomonas maltophilia.头孢地尔单独及与左氧氟沙星、米诺环素、多粘菌素B或复方磺胺甲恶唑联合使用对多重耐药嗜麦芽窄食单胞菌的活性。
Antimicrob Agents Chemother. 2020 Aug 20;64(9). doi: 10.1128/AAC.00559-20.
7
Activity of Potential Alternative Treatment Agents for Stenotrophomonas maltophilia Isolates Nonsusceptible to Levofloxacin and/or Trimethoprim-Sulfamethoxazole.潜在替代治疗剂对左氧氟沙星和/或复方磺胺甲噁唑不敏感的嗜麦芽窄食单胞菌分离株的活性。
J Clin Microbiol. 2020 Jan 28;58(2). doi: 10.1128/JCM.01603-19.
8
[Antimicrobial susceptibility patterns of clinical isolates of Pseudomonas cepacia (author's transl)].
Jpn J Antibiot. 1979 Oct;32(10):998-1002.
9
Comparative activity of antimicrobials against , and keratitis isolates.抗菌药物对 、 和 角膜炎分离株的活性比较。
Br J Ophthalmol. 2018 May;102(5):708-712. doi: 10.1136/bjophthalmol-2017-311751. Epub 2018 Feb 19.
10
Evaluation of Trimethoprim/Sulfamethoxazole (SXT), Minocycline, Tigecycline, Moxifloxacin, and Ceftazidime Alone and in Combinations for SXT-Susceptible and SXT-Resistant Stenotrophomonas maltophilia by In Vitro Time-Kill Experiments.评估体外时间杀菌实验中复方新诺明/磺胺甲恶唑（SXT）、米诺环素、替加环素、莫西沙星和头孢他啶单独及联合使用对 SXT 敏感和 SXT 耐药嗜麦芽窄食单胞菌的效果。
PLoS One. 2016 Mar 21;11(3):e0152132. doi: 10.1371/journal.pone.0152132. eCollection 2016.
引用本文的文献
1
Microtiter plate with built-in oxygen sensors: a novel approach to investigate the dynamics of Pseudomonas aeruginosa growth suppression in the presence of divalent cations and antibiotics.内置氧气传感器的微量滴定板：一种研究在二价阳离子和抗生素存在的情况下铜绿假单胞菌生长抑制动力学的新方法。
Arch Microbiol. 2022 May 4;204(6):297. doi: 10.1007/s00203-022-02877-y.
2
Overcoming Resistance for a More Rational Therapeutic Approach.克服耐药性以实现更合理的治疗方法。
Open Forum Infect Dis. 2022 Mar 21;9(5):ofac095. doi: 10.1093/ofid/ofac095. eCollection 2022 May.
3
Antimicrobial Susceptibility Testing for Polymyxins: Challenges, Issues, and Recommendations.多黏菌素类药物的药敏试验：挑战、问题和建议。
J Clin Microbiol. 2019 Mar 28;57(4). doi: 10.1128/JCM.01390-18. Print 2019 Apr.
4
Update on infections caused by Stenotrophomonas maltophilia with particular attention to resistance mechanisms and therapeutic options.嗜麦芽窄食单胞菌引起的感染最新情况，特别关注耐药机制和治疗选择。
Front Microbiol. 2015 Sep 2;6:893. doi: 10.3389/fmicb.2015.00893. eCollection 2015.
5
Stenotrophomonas maltophilia virulence and specific variations in trace elements during acute lung infection: implications in cystic fibrosis.嗜麦芽窄食单胞菌在急性肺部感染期间的毒力及微量元素的特定变化：对囊性纤维化的影响
PLoS One. 2014 Feb 28;9(2):e88769. doi: 10.1371/journal.pone.0088769. eCollection 2014.
6
Cation concentration variability of four distinct Mueller-Hinton agar brands influences polymyxin B susceptibility results.四种不同 Mueller-Hinton 琼脂品牌的阳离子浓度变异性影响多粘菌素 B 药敏试验结果。
J Clin Microbiol. 2012 Jul;50(7):2414-8. doi: 10.1128/JCM.06686-11. Epub 2012 May 2.
7
Stenotrophomonas maltophilia induced post-cataract-surgery endophthalmitis: Outbreak investigation and clinical courses of 26 patients.嗜麦芽窄食单胞菌引起的白内障术后眼内炎：26例患者的暴发调查及临床病程
Infection. 2009 Apr;37(2):117-22. doi: 10.1007/s15010-008-8150-8. Epub 2008 Dec 5.
8
Antimicrobial therapy for Stenotrophomonas maltophilia infections.嗜麦芽窄食单胞菌感染的抗菌治疗。
Eur J Clin Microbiol Infect Dis. 2007 Apr;26(4):229-37. doi: 10.1007/s10096-007-0279-3.
9
Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole: an increasing problem.对甲氧苄啶-磺胺甲恶唑耐药的嗜麦芽窄食单胞菌：一个日益严重的问题。
Ann Clin Microbiol Antimicrob. 2006 Sep 18;5:23. doi: 10.1186/1476-0711-5-23.
10
SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia.嗜麦芽窄食单胞菌的外膜多药外排蛋白SmeC
Antimicrob Agents Chemother. 2002 Feb;46(2):333-43. doi: 10.1128/AAC.46.2.333-343.2002.
本文引用的文献
1
Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.核酸衍生物拮抗剂。VIII. 生物化学相关抗代谢物组合中的协同作用。
J Biol Chem. 1954 Jun;208(2):477-88.
2
Pseudomonas maltophilia infections in man.嗜麦芽窄食单胞菌感染人类。
Am J Clin Pathol. 1969 Jan;51(1):58-61. doi: 10.1093/ajcp/51.1.58.
3
Nonfermentative gram-negative bacilli of nosocomial interest.医院感染相关的非发酵革兰氏阴性杆菌。
Am J Med. 1970 Jun;48(6):735-49. doi: 10.1016/s0002-9343(70)80009-2.
4
Antibiotic susceptibility testing by a standardized single disk method.采用标准化单纸片法进行抗生素敏感性试验。
Am J Clin Pathol. 1966 Apr;45(4):493-6.
5
Bacteremia with and without meningitis due to Yersinia enterocolitica, Edwardsiella tarda, Comamonas terrigena, and Pseudomonas maltophilia.由小肠结肠炎耶尔森菌、迟钝爱德华菌、土生丛毛单胞菌和嗜麦芽窄食单胞菌引起的伴有或不伴有脑膜炎的菌血症。
Ann N Y Acad Sci. 1970 Oct 30;174(2):488-502. doi: 10.1111/j.1749-6632.1970.tb45575.x.
6
Effect of different media on in vitro studies of antibiotic combinations.不同培养基对抗生素联合体外研究的影响。
Appl Microbiol. 1968 Jun;16(6):890-5. doi: 10.1128/am.16.6.890-895.1968.
7
Pseudomonas maltophilia endocarditis after replacement of the mitral valve: a case study.二尖瓣置换术后嗜麦芽窄食单胞菌性心内膜炎：病例报告
J Infect Dis. 1973 Nov;128:Suppl:771-3. doi: 10.1093/infdis/128.supplement_3.s771.
8
In vitro antibiotic susceptibility of pseudomonads other than Pseudomonas aeruginosa recovered from cancer patients.从癌症患者体内分离出的除铜绿假单胞菌外的假单胞菌的体外抗生素敏感性
Antimicrob Agents Chemother. 1972 Nov;2(5):344-9. doi: 10.1128/AAC.2.5.344.
9
Antibiotic susceptibility testing of Pseudomonas aeruginosa: selection of a control strain and criteria for magnesium and calcium content in media.铜绿假单胞菌的抗生素敏感性测试：对照菌株的选择及培养基中镁和钙含量的标准
J Infect Dis. 1974 Nov;130(5):454-63. doi: 10.1093/infdis/130.5.454.
10
Synergistic effect of combinations of sulfamethoxazole, trimethoprim, and colistin against Pseudomonas maltophilia and Pseudomonas cepacia.磺胺甲恶唑、甲氧苄啶和黏菌素联合使用对嗜麦芽窄食单胞菌和洋葱伯克霍尔德菌的协同作用。
Antimicrob Agents Chemother. 1974 Oct;6(4):521-3. doi: 10.1128/AAC.6.4.521.
Zotero 插件