大肠杆菌生长和静止细胞中细胞内蛋白质水解的代谢控制
Metabolic control of intracellular proteolysis in growing and resting cells of Escherichia coli.
作者信息
Pine M J
出版信息
J Bacteriol. 1966 Oct;92(4):847-50. doi: 10.1128/jb.92.4.847-850.1966.
Abstract
Pine, Martin J. (Roswell Park Memorial Institute, Buffalo, N.Y.). Metabolic control of intracellular proteolysis in growing and resting cells of Escherichia coli. J. Bacteriol. 92:847-850. 1966.-Protein breakdown was examined in Escherichia coli under varying conditions of growth and during nutritional deprivation. Optimal breakdown rates, estimated over short time periods of protein synthesis and decay, are invariant and unrepressible by any condition of growth or starvation. A more important aspect of metabolic control is manifest in the selection imposed by the physiological state of the cell for breakdown of limited populations of proteins. During the progress of growth, one-half to three-quarters of the protein susceptible in the resting state is progressively spared, and breakdown is continued in populations that are more selected and more frequently regenerated.
摘要
派恩，马丁·J.（纽约州布法罗市罗斯韦尔帕克纪念研究所）。大肠杆菌生长和静止细胞内蛋白质水解的代谢控制。《细菌学杂志》92:847 - 850。1966年。——在不同生长条件下以及营养剥夺期间，对大肠杆菌中的蛋白质分解进行了研究。在蛋白质合成和降解的短时间内估算的最佳分解速率是不变的，并且不受任何生长或饥饿条件的抑制。代谢控制的一个更重要方面体现在细胞生理状态对有限蛋白质群体分解的选择上。在生长过程中，处于静止状态时易被分解的蛋白质的一半到四分之三逐渐被保留下来，而在更多被选择且更频繁更新的蛋白质群体中继续进行分解。
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