Benedetti P, Antonozzi I, Curatolo P, Porro G
Arch Fr Pediatr. 1979 Jul-Aug;36(7):686-90.
The effect of age on the steady state levels of phenobarbitone, alone and when given with phenytoin, sodium valproate and ethosuccimide has been measured in 1 361 children whose ages ranged from one month to 12 years. The relationship between dose and plasma level differed in those under 2 years from those aged between 2 years and 12 years. The addition of the other drugs altered the pharmacokinetics of phenobarbitone.
在1361名年龄从1个月到12岁的儿童中，测量了年龄对苯巴比妥稳态水平的影响，以及苯巴比妥分别与苯妥英、丙戊酸钠和乙琥胺合用时的稳态水平。2岁以下儿童与2至12岁儿童的剂量与血浆水平关系有所不同。其他药物的添加改变了苯巴比妥的药代动力学。
