Eadie M J, Lander C M, Hooper W D, Tyrer J H
Proc Aust Assoc Neurol. 1976;13:89-96.
The relation between plasma phenobarbitone level and phenobarbitone dose was studied in 121 patients. The relation changed with age, the dosage requirement (on a day weight basis) tending to fall as patients grew older. Males under 5 years had a higher dosage requirement than females of the same age, but otherwise sex did not affect the relationship, nor did the concurrent intake of the anticonvulsants phenytoin, carbamazepine or sulthiame. In the individual, plasma phenobarbitone levels tended to increase out of proportion of dosage increases. These findings can provide a basis for prescribing appropriate phenobarbitone doses in epileptics.
对121例患者研究了血浆苯巴比妥水平与苯巴比妥剂量之间的关系。这种关系随年龄而变化，剂量需求（以每日体重为基础）往往随着患者年龄的增长而下降。5岁以下男性的剂量需求高于同龄女性，但除此之外，性别不影响这种关系，同时服用抗惊厥药苯妥英、卡马西平或舒噻美也不影响这种关系。就个体而言，血浆苯巴比妥水平的升高往往与剂量增加不成比例。这些发现可为癫痫患者开具合适的苯巴比妥剂量提供依据。
