Coulam C M, Warner H R, Wood E H, Bassingthwaighte J B
Circ Res. 1966 Nov;19(5):879-90. doi: 10.1161/01.res.19.5.879.
A method has been developed for computing the distribution of blood transit times (transfer function) from indicator-dilution curves recorded from upstream (aorta) and downstream (pulmonary artery, renal vein and coronary sinus) circulator sites in mongrel dogs. The method employs a Fourier series transformation of the upstream and downstream curves and yields a time-domain transfer function which is independent of recirculating dye particles. Discontinuities, created in the upstream and downstream indicator curves by the termination of sampling (120 sec postinjection), are removed by a tail terminating procedure which employs normal and lagged normal density distributions. The transfer functions computed for the trans-renal and trans-coronary circulations and their relationship to the systemic circulation dispersion patterns are shown under control conditions (pentobarbital anesthesia) and during intra-aortic infusion of angiotensin, acetylcholine and adenosine triphosphate. These distribution patterns reflect the response of the vascular system to the drugs and demonstrate, to a limited extent, the role which different vascular beds have in the cardiovascular mixing process.
已开发出一种方法，用于根据杂种犬上游（主动脉）和下游（肺动脉、肾静脉和冠状窦）循环部位记录的指示剂稀释曲线计算血液通过时间的分布（传递函数）。该方法采用上游和下游曲线的傅里叶级数变换，并产生一个与再循环染料颗粒无关的时域传递函数。通过终止采样（注射后120秒）在上游和下游指示剂曲线中产生的不连续性，通过采用正态和滞后正态密度分布的尾部终止程序来消除。在对照条件（戊巴比妥麻醉）下以及在主动脉内输注血管紧张素、乙酰胆碱和三磷酸腺苷期间，显示了为经肾和经冠状动脉循环计算的传递函数及其与体循环弥散模式的关系。这些分布模式反映了血管系统对药物的反应，并在一定程度上证明了不同血管床在心血管混合过程中的作用。
