Szent-Györgyi A, Együd L G, McLaughlin J A
Science. 1967 Feb 3;155(3762):539-41. doi: 10.1126/science.155.3762.539.
Many problems are left open in this article. Its publication may be excused by the suffering cancer causes, which urges the researcher to publish as soon as he thinks he may have found a new trail, which also may be taken by others. What emerges clearly is that SH groups, with their specific reactivities, offer a hopeful target in the search for cancerostatic substances, among which the natural repressor of cell division may hold out the most promise. The glyoxal derivatives also have antiviral properties (7, 16) and may be in the center of a hitherto unknown system of equilibria which deserves a thorough study. The low molecular weight of the glyoxal derivative reported justifies the hope of an early clarification of its structure, as well as its synthesis (17).
本文留下了许多未解决的问题。鉴于癌症所带来的痛苦,这篇文章的发表或许情有可原,它促使研究者一旦认为可能发现了新线索就尽快发表,而这些线索其他人也可能会采用。显而易见的是,具有特定反应活性的巯基基团在寻找抗癌物质方面提供了一个有希望的靶点,其中细胞分裂的天然抑制剂可能最具前景。乙二醛衍生物也具有抗病毒特性(7, 16),并且可能处于一个迄今未知的平衡体系的核心,这值得深入研究。所报道的乙二醛衍生物的低分子量使得有望早日阐明其结构并实现其合成(17)。