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光诱导的DNA-蛋白质交联与细菌杀伤:低温下的相关性

Photoinduced DNA-protein cross-links and bacterial killing: a correlation at low temperatures.

作者信息

Smith K C, O'Leary M E

出版信息

Science. 1967 Feb 24;155(3765):1024-6. doi: 10.1126/science.155.3765.1024.

Abstract

The increased sensitivity of Escherichia coli to killing by ultraviolet irradiation when frozen and the variation in this sensitivity as a function of the temperature during irradiation have been correlated with changes in the amount of DNA that was cross-linked to protein by ultraviolet light. These variations in sensitivity to killing do not correlate with the production of thymine dimers.

摘要

冷冻时大肠杆菌对紫外线照射杀伤的敏感性增加,以及这种敏感性随照射期间温度的变化,已与紫外线使DNA与蛋白质交联的量的变化相关联。这些杀伤敏感性的变化与胸腺嘧啶二聚体的产生无关。

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