对乙酰氨基酚在离体灌注大鼠肝脏中的代谢以及小肠对胆汁中对乙酰氨基酚结合物的进一步代谢。 - Suppr

Suppr

超能文献

Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine.

作者信息

Grafström R, Ormstad K, Moldéus P, Orrenius S

出版信息

Biochem Pharmacol. 1979 Dec 15;28(24):3573-9. doi: 10.1016/0006-2952(79)90402-7.

DOI:10.1016/0006-2952(79)90402-7

PMID:533560

Abstract

摘要

相似文献

Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine.对乙酰氨基酚在离体灌注大鼠肝脏中的代谢以及小肠对胆汁中对乙酰氨基酚结合物的进一步代谢。

Biochem Pharmacol. 1979 Dec 15;28(24):3573-9. doi: 10.1016/0006-2952(79)90402-7.

Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.对乙酰氨基酚在大鼠和小鼠离体肝细胞中的代谢与毒性

Biochem Pharmacol. 1978;27(24):2859-63. doi: 10.1016/0006-2952(78)90201-0.

Mechanism of inhibition of hepatic bioactivation of paracetamol by dimethyl sulfoxide.二甲基亚砜抑制对乙酰氨基酚肝脏生物活化的机制。

Drug Metabol Drug Interact. 1988;6(3-4):413-24. doi: 10.1515/dmdi.1988.6.3-4.413.

Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats.苯巴比妥、佛尔酮和四氯化碳预处理对大鼠对乙酰氨基酚胆汁排泄的影响。

Arch Int Pharmacodyn Ther. 1985 Jun;275(2):180-8.

The effect of cimetidine and ranitidine on paracetamol glucuronidation and sulphation in cultured rat hepatocytes.西咪替丁和雷尼替丁对培养的大鼠肝细胞中对乙酰氨基酚葡萄糖醛酸化和硫酸化的影响。

Biochem Pharmacol. 1985 May 1;34(9):1415-21. doi: 10.1016/0006-2952(85)90678-1.

Altered biliary excretion of acetaminophen in rats fed ethanol chronically.长期摄入乙醇的大鼠对乙酰氨基酚的胆汁排泄发生改变。

Drug Metab Dispos. 1984 Jan-Feb;12(1):20-4.

Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver.地奥司明和香叶木素在大鼠肝脏灌流中的药代动力学研究。

Xenobiotica. 1993 Dec;23(12):1345-52. doi: 10.3109/00498259309059444.

Regulation of glucuronidation and sulfate conjugation in isolated hepatocytes.离体肝细胞中葡萄糖醛酸化和硫酸结合反应的调节

Drug Metab Dispos. 1979 Nov-Dec;7(6):416-9.

Predictive value of liver slices for metabolism and toxicity in vivo: use of acetaminophen as a model hepatotoxicant.肝切片对体内代谢和毒性的预测价值：以对乙酰氨基酚作为模型肝毒性物质的应用

Toxicol Appl Pharmacol. 1993 Sep;122(1):108-16. doi: 10.1006/taap.1993.1178.

Sulphation and glucuronidation of paracetamol in human liver: assay conditions.对乙酰氨基酚在人肝脏中的硫酸化和葡萄糖醛酸化：测定条件

Biochem Pharmacol. 1988 Nov 15;37(22):4405-7. doi: 10.1016/0006-2952(88)90624-7.

引用本文的文献

Sulfhydrylated albumin mitigates Acetaminophen-induced liver injury by restoring the integrated HS-albumin thiol antioxidant network.巯基化白蛋白通过恢复完整的HS-白蛋白硫醇抗氧化网络减轻对乙酰氨基酚诱导的肝损伤。

Redox Biol. 2025 Jul 17;85:103774. doi: 10.1016/j.redox.2025.103774.

Investigation of Intestinal Absorption and Excretion of Paracetamol in Streptozotocin-Induced Hyperglycemia.链脲佐菌素诱导的高血糖症中对乙酰氨基酚肠吸收和排泄的研究。

Int J Mol Sci. 2022 Oct 7;23(19):11913. doi: 10.3390/ijms231911913.

Expression of Drug Pump Protein MRP2 in Lipopolysaccharide-Treated Rats and its Impact on the Disposition of Acetaminophen.脂多糖处理大鼠中药物转运蛋白MRP2的表达及其对乙酰氨基酚处置的影响

Iran J Pharm Res. 2011 Fall;10(4):855-9.

Effect of phenobarbital and p-hydroxyphenobarbital glucuronide on acetaminophen metabolites in isolated rat hepatocytes: use of a kinetic model to examine the rates of formation and egress.苯巴比妥和对羟基苯巴比妥葡萄糖醛酸苷对分离的大鼠肝细胞中对乙酰氨基酚代谢产物的影响：利用动力学模型研究生成和流出速率

J Pharmacokinet Biopharm. 1993 Apr;21(2):175-94. doi: 10.1007/BF01059769.

Pharmacokinetic study of the fate of acetaminophen and its conjugates in rats.对乙酰氨基酚及其共轭物在大鼠体内代谢转归的药代动力学研究。

J Pharmacokinet Biopharm. 1983 Jun;11(3):245-72. doi: 10.1007/BF01061867.

Paracetamol overdosage. Pharmacological considerations and clinical management.对乙酰氨基酚过量。药理学考量与临床处理

Drugs. 1983 Mar;25(3):290-314. doi: 10.2165/00003495-198325030-00002.

The role of glutathione in detoxication.谷胱甘肽在解毒中的作用。

Environ Health Perspect. 1983 Mar;49:59-69. doi: 10.1289/ehp.834959.

Pharmacokinetic interactions between indomethacin and paracetamol in the rat.吲哚美辛与对乙酰氨基酚在大鼠体内的药代动力学相互作用。

Pharm Weekbl Sci. 1985 Feb 22;7(1):15-9. doi: 10.1007/BF01962864.

Is biliary excretion of paracetamol significant in man?对乙酰氨基酚在人体中的胆汁排泄量可观吗？

Br J Clin Pharmacol. 1986 Sep;22(3):363-6. doi: 10.1111/j.1365-2125.1986.tb02902.x.

Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat.胆管插管和丁硫氨酸亚砜胺预处理对Fischer 344大鼠对乙酰氨基酚肾毒性的影响。

Arch Toxicol. 1990;64(1):14-25. doi: 10.1007/BF01973371.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验