大肠杆菌中芳香族生物合成第一步反应所涉及的同工酶的遗传与生化分析。
Genetic and biochemical analysis of the isoenzymes concerned in the first reaction of aromatic biosynthesis in Escherichia coli.
作者信息
Wallace B J, Pittard J
出版信息
J Bacteriol. 1967 Jan;93(1):237-44. doi: 10.1128/jb.93.1.237-244.1967.
Abstract
Mutant strains of Escherichia coli K-12 were isolated possessing mutations which affected the tyrosine-inhibitable 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase, the phenylalanine-inhibitable DAHP synthetase, or the tryptophan-repressible DAHP synthetase. The mutations causing the loss of each of these activities have been mapped and are widely separated from each other on the E. coli chromosome. Chromatography on diethylaminoethyl cellulose columns allowed the recognition of four peaks of activity.
摘要
分离出了大肠杆菌K-12的突变菌株，这些菌株具有影响酪氨酸可抑制的3-脱氧-D-阿拉伯庚酮糖酸-7-磷酸（DAHP）合成酶、苯丙氨酸可抑制的DAHP合成酶或色氨酸可阻遏的DAHP合成酶的突变。导致这些活性丧失的突变已被定位，并且在大肠杆菌染色体上彼此相距很远。在二乙氨基乙基纤维素柱上进行色谱分析可识别出四个活性峰。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Hyper-production of beta-galactosidase by Escherichia coli bacteria.大肠杆菌超量生产β-半乳糖苷酶。
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FALSE FEEDBACK INHIBITION OF AROMATIC AMINO ACID BIOSYNTHESIS BY BETA-2-THIENYLALANINE.β-2-噻吩丙氨酸对芳香族氨基酸生物合成的假反馈抑制作用
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END-PRODUCT REGULATION OF THE GENERAL AROMATIC-PATHWAY IN ESCHERICHIA COLI W.大肠杆菌W中一般芳香族途径的终产物调节
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